Imaging Modalities

Positron Emission Tomography

Preclinical PET is essential tool in drug developement, especially for tumour pharmaceuticals and brain investigations. At our site a nanoScan PET/MRI scanner includes the high-end PETdetector ring avalable on the market, that ensures the best PET image quality for our biology applications. The greatest advantage of PET is the exeptional sensitivity of the technique that can reach the picomolar levels (10-12 mol/L). Moreover, this gives us the opportunity to investigate very small amount of molecules, their functional roles in biological models, or even their bindig properties to special cell surface proteins such as membrane transporters. Furthermore, PET gives us the opportunity of quantitative imaging, that means the exact amount of the radioactivity can be measured on the images. Therefore, quantitative region of interest (ROI) analysis can be derived for example about tumor glucose uptake. Our PET can offer:

- High spatial resolution (0.3 mm with Tera-Tomo™​​​​​​​ 3D reconstruction)
- High sensitivity imaging (8 %)
- Large bore size: 12 cm transaxial field of view, 10 cm axial field of view

- Gated PET: cardiac and lung motion gated acquisition for better image quality
 Quantitative ROI (region of interest) analysis

We provide the following services with our nanoScan PET/MRI system:
- Physiology characterization of biological models, especially mice and rats
- Imaging solutions for the visualisation of tumor hypoxia and angiogenesis
- Quantitative tumor imaging in mice and rats for the investigation of new anticancer pharmaceuticals
- Quantitative brain imaging in mice and rats for the investigation of brain normal/abnormal physiology and deseases
- Visualisation of cell surface receptor binding locations in mice and rats

 

 

Magnetic Resonance Imaging

Our laboratory can provide meticulous care prepared, three dimensional MRI-images from biological models, technical and industrial samples. We can perform in vitro and in vivo imaging, as well. The MRI method is very suitable for investigation of soft-tissue, grease, cream or liquid structured samples, composites which contain valuable amount of water or/and hydrocarbons. MRI based on relaxation dynamics of the rotating magnetic moments of Hydrogen nuclei of water or/and hydrocarbons of samples. Many innovative and high technical applications can be supported by the method in biology, chemistry, physics and engineering. Our 1T MRI system can provide: 

- Gradient strength: 450 mT/m
-  ≤ 100 μm spatial resolution 
- Quick sagittal Localiser for ultrafast anatomical reference
- Spin Echo (SE) 2D and 3D
- Fast Spin Echo (FSE) 2D and 3D
- Gradient echo 3D (GRE)
- Inversion Recovery – Spin and Gradient Echo (IR-SE, IR-GRE)
- Fat-water imaging (Dixon-method)
- Perfusion imaging
- T1, T2 and T2*-mapping
- Echo Planar Imaging (EPI)
- Fat-suppression with IR FSE (STIR)
- Magnetic Resonance Spectroscopy (MRS)

We provide the following services with the nanoScan PET/MRI system:

- Description of anatomy of in vivo and in vitro biological models.
- Distinction between water, fat and high proton density areas of tissues.
- Anatomical support for nuclear imaging methods.
- Investigation, and characterization of industrial greases, lubricants and hydrocarbons.
- Investigation of food industry products.

 

Single Photon Emission Computed Tomography

Preclinical SPECT gained importance in small animal imaging for drug developement studies, because of the flexibility in monitoring the physiological alterations with the help of radioactively labeled target molecules. One of the greatest advantage of SPECT is the exeptional sensitivity of this technique that can reach below nanomolar levels (10-11 mol/L). At our site the Mediso nanoSPECT/CT provides images of excelent quality using Resolution-booster™, the first ground breaking total detection chain design principle along with the patented* M3-pinhole™ and Tera-Tomo™ 3D SPECT reconstruction technology. Our SPECT can offer:

- High sensitivity: 13000 cps/MBq
- Full stationary imaging (in 1 - 3 seconds)

- Exeptional spatial resoltion of 0.3 mm (with mouse focused collimator)
- Multipinhole stationary imaging (quantitativity with 1mm resolution)
- Energy resolution <9.5 %
- Exeptional image quality for large size animals (rabbits)

We provide the following services with the nanoScan SPECT/CT system:
- Physiology characterization of biological models: mice, rats or rabbits
- Imaging solutions for the visualisation of tumor hypoxia and angiogenesis
- Tumor imaging in mice and rats for the investigation of new anticancer pharmaceuticals
- Brain imaging in mice and rats for the investigation of brain normal/abnormal physiology and deseases
- Visualisation of cell surface receptor binding locations

 

X-ray Computed Tomography

Our SPECT/CT system includes an micro CT scanner with an 80W tube power and a flatpanel detector. We use this nondestructive technique for visualizing interior features within biological, preclinical, physical or industrial samples. The gray levels of the reconstructed 3D CT image volumes correspond to X-ray attenuation. This reflects the proportion of scattered or absorbed X-rays for each voxel. Our CT can offer:

- High spatial resolution (0.01 mm)
- 3 different zoom options with high image quality (from 1.25 to 7.6)

- Different size animals (from mouse to rabbit)
- Target visualization during the scan (real time reconstruction)
- Fast scanning time (36 sec for a whole body mouse)
- High throughput (more than 30 animals in an hour)

We provide the following services with the nanoScan SPECT/CT system:
- Anatomy characterization of biological models, in particular for the detection of bone tissue.
- Anatomy support for other nuclear imaging techniques.
- Investigation of solid physical, geophysical and industrial samples.
- Preparing enlarged images from tiny parts and details, of an organization or physical structure.
- Measuring size and spatial distribution of particles or selected parts of the investigated sample.
- Nondestructive volumetric investigation of rare specimens.
- Nondestructive discovering of errors during industrial manufacturing.
- Scout porous parts, cracks and inclusions in solid materials.
- Static and dynamic visualization of samples in steady state and in transient state.
- Nondestructive visualization of electronic structures, chips and fabrication errors of products.